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[急性危及生命的紧张症与恶性抗精神病药物综合征的鉴别诊断——病例报告]

[Differential diagnosis of acute life threatening catatonia and malignant neuroleptic syndrome--a case report].

作者信息

Hermle L, Oepen G

出版信息

Fortschr Neurol Psychiatr. 1986 Jun;54(6):189-95. doi: 10.1055/s-2007-1001864.

Abstract

This study reports the development of a severe life threatening catatonia in a 19 years old woman. Initially she displayed paranoia and hallucinations, which were complicated under neuroleptic treatment by extended rigor, temperature and autism. ECT led to a certain improvement of all symptoms, but complete recovery was only reached after neuroleptic drug withdrawal. The course of this case shows that the differential-diagnosis between genuine "pernicious" catatonia and the neuroleptica malignant syndrome is very difficult clinically. Therefore, before the application of ECT, an observation period without any neuroleptic drugs is recommended in similar cases with rigor, stupor and raised temperature, to avoid additional risks by narcosis and ECT itself. Diagnostic and therapeutic outlines are given.

摘要

本研究报告了一名19岁女性出现严重危及生命的紧张症。起初,她表现出妄想和幻觉,在接受抗精神病药物治疗后,病情因全身僵硬、体温异常和孤独症样状态而复杂化。电休克治疗使所有症状有一定改善,但仅在停用抗精神病药物后才完全康复。该病例的病程表明,临床上真正的“恶性”紧张症与抗精神病药物恶性综合征之间的鉴别诊断非常困难。因此,在类似出现全身僵硬、木僵和体温升高的病例中,在应用电休克治疗之前,建议有一个不使用任何抗精神病药物的观察期,以避免麻醉和电休克治疗本身带来的额外风险。文中给出了诊断和治疗概述。

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