Hirakawa H, Iijima H, Gohdo T, Tsukahara S
Department of Ophthalmology, Yamanashi Medical University, Tamaho, Japan.
Am J Ophthalmol. 1999 Aug;128(2):185-91. doi: 10.1016/s0002-9394(99)00100-2.
To detect cystoid macular edema in consecutive eyes with retinitis pigmentosa by means of optical coherence tomography and to study the correlation between cross-sectional structures and angiographic findings in cystoid macular edema.
In a prospective study, cross-sectional images through the fovea were evaluated by means of optical coherence tomography in 89 phakic eyes of 46 patients with retinitis pigmentosa. Eyes showing cystoid appearance in the macula in the optical coherence tomographic images were further studied with measurement of the dimensions of cystoid lesions and with a fluorescein angiogram either at 18 minutes after dye injection or later.
Cystoid lesions were observed in the macula in optical coherence tomographic images in 12 eyes in six (13%) of 46 patients. In these eyes, the width of total area of the cystoid lesions was positively correlated with the grade of fluorescein angiogram (Spearman rank correlation coefficient, r = .629; P = .029), but the thickness of the neurosensory retina at the center of the fovea was not. Among three variables for grading cystoid macular edema, consisting of angiographic grade, thickness of the neurosensory retina at the center of the fovea, and width of total area of the cystoid lesions, only the last measure was significantly correlated with best-corrected visual acuity (Pearson correlation coefficient, r = .693; P = .012).
Cystoid macular edema in eyes with retinitis pigmentosa could easily be detected with the use of optical coherence tomography independent of the angiographic degree of dye leakage. The size of cystoid lesions demonstrated in the optical coherence tomographic images, especially the thickness of the neurosensory retina at the center of the fovea, was not necessarily correlated with the angiographic grading of dye leakage. Measurement of the width of total area of the cystoid lesions in the optical coherence tomographic images is significantly correlated with the loss of visual acuity.
通过光学相干断层扫描检测连续性视网膜色素变性患者眼中的黄斑囊样水肿，并研究黄斑囊样水肿的横断面结构与血管造影结果之间的相关性。
在一项前瞻性研究中，对46例视网膜色素变性患者的89只屈光间质完整的眼睛进行了光学相干断层扫描，评估通过中央凹的横断面图像。在光学相干断层扫描图像中显示黄斑呈囊样外观的眼睛，进一步测量囊样病变的大小，并在注射染料后18分钟或更晚进行荧光素血管造影。
在46例患者中的6例（13%）的12只眼中，光学相干断层扫描图像显示黄斑存在囊样病变。在这些眼中，囊样病变总面积的宽度与荧光素血管造影分级呈正相关（Spearman等级相关系数，r = 0.629；P = 0.029），但中央凹中心神经感觉视网膜的厚度与之无关。在用于评估黄斑囊样水肿的三个变量中，即血管造影分级、中央凹中心神经感觉视网膜的厚度和囊样病变总面积的宽度，只有最后一项测量与最佳矫正视力显著相关（Pearson相关系数，r = 0.693；P = 0.012）。
使用光学相干断层扫描可轻松检测视网膜色素变性患者眼中的黄斑囊样水肿，且与染料渗漏的血管造影程度无关。光学相干断层扫描图像中显示的囊样病变大小，尤其是中央凹中心神经感觉视网膜的厚度，不一定与染料渗漏的血管造影分级相关。光学相干断层扫描图像中囊样病变总面积宽度的测量与视力丧失显著相关。
