Gorovoy Ian R, Gallagher Denise S, Eller Andrew W, Mayercik Vera A, Friberg Thomas R, Schuman Joel S
University of California, San Francisco, Department of Ophthalmology, San Francisco, California, USA.
Semin Ophthalmol. 2013 Mar;28(2):79-83. doi: 10.3109/08820538.2012.760614.
To describe the occurrence of cystoid macular edema (CME) in the setting of central foveal thickness (CFT) under 250 μm as measured by optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP).
Stratus OCT was used to measure CFT in a total of 90 eyes from 46 patients with RP. Cross-sectional OCT images were also evaluated for CME, which was defined as cystoid changes in the macula seen on at least two linear scans.
CME was identified in 13 of the 46 patients or in 22 of 90 eyes by OCT. In eyes with macular edema, CFT ranged from 224 to 718 μm (mean = 339 ± 137 μm). In eyes without macular edema, CFT ranged from 99 to 273 μm (mean = 184 ± 40 μm). Bilateral CME occurred in 9 of 13 patients (69%). CFT was considered "normal" in 7 of the 22 eyes (32%) with CME. Two patients had bilateral CME with normal CFTs, under 250 μm.
We demonstrate the occurrence of CME in RP patients without associated thickening, which has not been described. This concept likely is applicable to other diseases with retinal thinning.
描述视网膜色素变性（RP）患者中，经光学相干断层扫描（OCT）测量中央凹厚度（CFT）低于250μm时囊样黄斑水肿（CME）的发生情况。
使用Stratus OCT对46例RP患者的90只眼睛进行CFT测量。还对横断面OCT图像进行CME评估，CME定义为在至少两次线性扫描中黄斑出现的囊样改变。
经OCT检查，46例患者中有13例、90只眼中有22只眼发现CME。存在黄斑水肿的眼睛，CFT范围为224至718μm（平均 = 339 ± 137μm）。无黄斑水肿的眼睛，CFT范围为99至273μm（平均 = 184 ± 40μm）。13例患者中有9例（69%）发生双侧CME。22只患有CME的眼睛中有7只（32%）CFT被认为“正常”。两名患者双侧CME且CFT正常，低于250μm。
我们证明了RP患者在无相关增厚情况下CME的发生，这尚未见报道。这一概念可能适用于其他视网膜变薄的疾病。
