Berkovskiĭ A L, Sergeeva E V, Kachalova N D, Prostakova T M, Kozlov A A
Klin Lab Diagn. 1999 Jun(6):18-20.
A simple and sensitive method for estimation of activated partial thromboplastin time (APTT) is developed, making use a complex reagent containing the activator (plant phospholipids) and contact factor (ellagic acid). The test requires additionally only 0.025 M CaCl2. The test is more sensitive to the presence of heparin in the blood and to insufficiency of blood clotting factors VIII and IX than the reagents containing insoluble substances (kaolin and animal phosphatides). Addition of soluble ellagic acid into reagent for APTT estimation allows studies on optic coagulometers.
开发了一种简单且灵敏的活化部分凝血活酶时间（APTT）测定方法，该方法使用了一种含有激活剂（植物磷脂）和接触因子（鞣花酸）的复合试剂。该检测仅额外需要0.025M氯化钙。与含有不溶性物质（高岭土和动物磷脂）的试剂相比，该检测对血液中肝素的存在以及凝血因子VIII和IX的不足更为敏感。在用于APTT测定的试剂中添加可溶性鞣花酸可用于光学凝血计的研究。
