Lindell S G, Suomi S J, Shoaf S, Linnoila M, Higley J D
Laboratory of Comparative Ethology, National Institute on Child Health and Human Development, Poolesville, Maryland 20837-0529, USA.
Biol Psychiatry. 1999 Aug 15;46(4):568-72. doi: 10.1016/s0006-3223(99)00037-2.
Central nervous system (CNS) serotonin deficits have been linked to many pathological behaviors in both human and nonhuman primates. The plasma prolactin response to fenfluramine has been widely used to assess CNS serotonin functioning in humans. Prolactin is also found as an integrated measure in saliva. We hypothesized that salivary prolactin concentrations would correlate positively with cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) in rhesus monkeys. Twenty-seven adult male and female rhesus macaques (Macaca mulatta) were sampled for concurrent saliva, blood, and CSF. Saliva and blood serum were assayed for prolactin concentrations, and CSF was assayed for 5-HIAA, homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). Salivary prolactin concentrations were positively correlated with CSF 5-HIAA concentrations. No other relationships between any of the measures, including that between salivary prolactin and serum prolactin, were found to be statistically significant. These findings suggest the possibility of using salivary prolactin concentrations as an index of CNS serotonin turnover in humans.
中枢神经系统（CNS）血清素缺乏与人类和非人类灵长类动物的许多病理行为有关。血浆催乳素对芬氟拉明的反应已被广泛用于评估人类中枢神经系统血清素的功能。催乳素也被发现是唾液中的一种综合测量指标。我们假设恒河猴唾液中催乳素浓度与脑脊液（CSF）5-羟吲哚乙酸（5-HIAA）呈正相关。对27只成年雄性和雌性恒河猴（猕猴）同时采集唾液、血液和脑脊液样本。检测唾液和血清中的催乳素浓度，检测脑脊液中的5-HIAA、高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）。唾液中催乳素浓度与脑脊液中5-HIAA浓度呈正相关。在任何测量指标之间，包括唾液催乳素和血清催乳素之间，未发现其他具有统计学意义的关系。这些发现表明，有可能将唾液中催乳素浓度用作人类中枢神经系统血清素周转率的指标。
