Yamadera H, Suzuki H, Nakamura S, Endo S
Department of Neuropsychiatry, Nippon Medical School Tokyo, Japan.
Psychiatry Clin Neurosci. 1999 Apr;53(2):189-91. doi: 10.1046/j.1440-1819.1999.00531.x.
Polysomnography, blood concentration and core body temperature recordings were performed on 12 healthy volunteers with administration of trazodone and placebo. Trazodone increased slow wave sleep (SWS), and decreased the average, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with amplitude (the difference between the highest and lowest temperature) and %SWS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.
对12名健康志愿者在服用曲唑酮和安慰剂的情况下进行了多导睡眠图、血药浓度和核心体温记录。与安慰剂相比，曲唑酮增加了慢波睡眠（SWS），并显著降低了平均、最高和最低核心体温。曲唑酮的血药浓度与分为三个阶段的睡眠阶段第一阶段的振幅（最高和最低温度之间的差值）和SWS百分比呈正相关，与最低温度呈负相关。最低温度的出现时间与SWS百分比呈负相关。
