Yamadera H, Nakamura S, Suzuki H, Endo S
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Psychiatry Clin Neurosci. 1998 Aug;52(4):439-43. doi: 10.1046/j.1440-1819.1998.00403.x.
Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.
对8名健康男性使用盐酸曲唑酮、丙咪嗪和安慰剂进行多导睡眠图监测。盐酸曲唑酮显著增加慢波睡眠。丙咪嗪延长快速眼动（REM）潜伏期并显著降低REM睡眠百分比。曲唑酮减少1期和2期睡眠，而丙咪嗪增加该阶段睡眠。这些发现表明，曲唑酮的抗抑郁作用可能与丙咪嗪不同，在于其对REM睡眠的抑制作用。
