Harhangi H R, Sun X, Wang Y X, Akhmanova A, Miedema K, Heyting C, Hennig W
Department of Physiological Chemistry and Pathobiochemistry, Johannes-Gutenberg University, Duesbergweg 6, D-55099 Mainz, Germany.
Chromosoma. 1999 Aug;108(4):235-42. doi: 10.1007/s004120050373.
A new chromosomal protein - RADHA - of Drosophila is described that is specific for the male germ line. It is encoded by a single-copy gene, located in the region 96C-D of D. melanogaster polytene chromosomes. Transcription of the radha gene is restricted to the primary spermatocyte stage. The protein initially accumulates in some of the Y-chromosomal lampbrush loops. After meiosis it is found in the nuclei of spermatids and might be involved in chromatin rearrangement processes in the male germ line. RADHA is a basic protein with a C-terminal leucine zipper region and several segments capable of forming coiled-coil structures.
本文描述了一种新的果蝇染色体蛋白——RADHA，它对雄性生殖系具有特异性。它由一个单拷贝基因编码，位于黑腹果蝇多线染色体的96C-D区域。radha基因的转录仅限于初级精母细胞阶段。该蛋白最初在一些Y染色体灯刷环中积累。减数分裂后，它存在于精子细胞核中，可能参与雄性生殖系中的染色质重排过程。RADHA是一种碱性蛋白，具有C端亮氨酸拉链区域和几个能够形成卷曲螺旋结构的片段。
