Mierau G W
Special Anatomical Pathology, The Children's Hospital, Denver, Colorado, USA.
Histopathology. 1999 Aug;35(2):99-101. doi: 10.1046/j.1365-2559.1999.0741a.x.
The histopathological diagnosis of tumours has been transformed by immunohistochemistry. Used with experience and judgement, a panel of antibodies or antisera, combined when necessary with antigen retrieval, will enable the accurate typing of most problematic tumours. This has led many histopathologists to question whether the electron microscope has any residual utility for tumour diagnosis; the machines are large, costly to purchase and maintain, and will accept only minute samples of tissue. The following articles by Mierau and by Eyden, both strong advocates, comment on the current and future role of electron microscopy in tumour diagnosis.
免疫组织化学改变了肿瘤的组织病理学诊断。凭借经验和判断力使用一组抗体或抗血清，并在必要时结合抗原修复，能够对大多数疑难肿瘤进行准确分型。这使得许多组织病理学家质疑电子显微镜在肿瘤诊断中是否还有任何剩余用途；电子显微镜体积庞大，购置和维护成本高昂，而且只接受极小的组织样本。以下由米劳和艾登撰写的文章，两位都是坚定的支持者，对电子显微镜在肿瘤诊断中的当前和未来作用进行了评论。
