Schroeder C, Osman A A, Roggenbuck D, Mothes T
German Primate Centre, Göttingen.
Nephrol Dial Transplant. 1999 Aug;14(8):1875-80. doi: 10.1093/ndt/14.8.1875.
Marmosets in captivity are highly susceptible to wasting marmoset syndrome (WMS), the aetiology of which is still not fully determined.
The level of IgA-gliadin antibodies (IgA-AGA), of IgA-containing circulating immune complexes (IgA-CIC), and the degree of glomerular IgA deposits were compared between marmosets suffering from WMS and animals not affected by the disorder.
Both IgA-AGA and IgA-CIC were demonstrable in all groups of monkeys investigated. IgA-AGA and IgA-CIC were significantly higher in monkeys with WMS than in non-affected animals. There was a significant correlation between the glomerular IgA-deposition and titre of IgA-AGA. The group of marmosets strongly positive for glomerular IgA deposits comprised significantly more animals suffering from WMS than the group without deposits. In the diet of the animals a considerable amount of gliadin-like cereal proteins was assayed.
There are several parallels between the human disorders (coeliac disease and IgA-nephropathy/Berger's disease) and the changes observed in WMS. It should be further investigated if WMS in marmosets is a suitable animal model for both human diseases.
圈养的狨猴极易患狨猴消瘦综合征（WMS），其病因仍未完全明确。
比较了患WMS的狨猴与未患该疾病的动物之间的IgA-麦醇溶蛋白抗体（IgA-AGA）水平、含IgA的循环免疫复合物（IgA-CIC）水平以及肾小球IgA沉积程度。
在所有研究的猴群中均检测到了IgA-AGA和IgA-CIC。患WMS的猴子的IgA-AGA和IgA-CIC显著高于未患病动物。肾小球IgA沉积与IgA-AGA滴度之间存在显著相关性。肾小球IgA沉积强阳性的狨猴组中患WMS的动物明显多于无沉积组。在动物饮食中检测到了大量麦醇溶蛋白样谷物蛋白。
人类疾病（乳糜泻和IgA肾病/伯杰氏病）与WMS中观察到的变化之间存在若干相似之处。狨猴的WMS是否是这两种人类疾病的合适动物模型有待进一步研究。
