Yambe T, Kawano S, Nanka S, Kobayashi S, Tanaka A, Owada N, Yoshizawa M, Abe K, Tabayashi K, Takeda H, Hashimoto H, Nitta S
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Artif Organs. 1999 Aug;23(8):747-50. doi: 10.1046/j.1525-1594.1999.06415.x.
For development aimed at a totally implantable type ventricular assist device (VAD), the vibrating flow pump (VFP) has been developed at Tohoku University. A transcutaneous energy transmission system (TETS) using amorphous fibers was developed to power the totally implantable VAD system. The VFP works at a high frequency compared to that of a natural heart of a biological system. It is a frequency of 10-50 Hz. In this research, animal experiments with left heart bypass were carried out with healthy adult goats. For comparison between nonpulsatile flow and oscillated flow, a rotary pump (RP) and the VFP were used in the experiments. For the achievement of total left heart bypass, left ventricular approaches were carried out, and blood was pumped from the left ventricle to the descending aorta. Adequate support of the left heart was provided by both pumps. In terms of the results, the vascular resistances tended to decrease during the use of both pumps during 100% bypass driving. When we compared these pumps at the same flow rate, the resistances during RP driving were significantly smaller than those during VFP driving. These results may suggest that the influences of the VFP upon the peripheral vessels may be relatively small compared to those of the RP. This may be an important result when a stable hemodynamic condition is required during artificial circulation. The VFP was considered as a candidate for a totally implantable VAD as a result.
为了开发一种完全可植入式心室辅助装置（VAD），东北大学研制了振动流泵（VFP）。开发了一种使用非晶纤维的经皮能量传输系统（TETS），为完全可植入式VAD系统提供动力。与生物系统的天然心脏相比，VFP工作频率较高，为10 - 50Hz。在本研究中，对健康成年山羊进行了左心旁路动物实验。为了比较非搏动流和振荡流，实验中使用了旋转泵（RP）和VFP。为了实现完全左心旁路，采用左心室入路，将血液从左心室泵入降主动脉。两种泵都能为左心提供充分支持。结果显示，在100%旁路驱动期间，两种泵使用过程中血管阻力均有下降趋势。当我们在相同流速下比较这两种泵时，RP驱动期间的阻力明显小于VFP驱动期间的阻力。这些结果可能表明，与RP相比，VFP对外周血管的影响可能相对较小。在人工循环过程中需要稳定的血流动力学状态时，这可能是一个重要结果。因此，VFP被认为是完全可植入式VAD的一个候选方案。
