Kobayashi S, Nitta S, Yambe T, Sonobe T, Nannka S, Shizuka K, Fkuju T, Hashimoto H
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Int J Artif Organs. 1998 Apr;21(4):225-8.
Vibrating flow pump (VFP) can generate high frequency oscillated blood flow within 10-40 Hz. In this study, new type VFP was developed as a ventricular assist device. Left Ventricular assist circulation using VFP were performed as aseptic animal experiments using goats. hemodynamic parameters were recorded continuously at awake state. Driving frequency of VFP was 25 Hz and pump flow rate was controlled to approximately 2 l/min. Frequency of VFP was 25 hz and pump flow rate was controlled to approximately 2 L/min. Frequency analysis method was used for analyzing hemodynamics. The peak of power was observed at 25 Hz from the Fourier transformation of blood flow waveform. Systemic vascular resistance was decreased by the start of left ventricular assistance using oscillated blood flow. No fatal arrhythmia was observed during this study. As the conclusion, new type VFP has a sufficient performance for left ventricular assistance. Small size blood pump may be enabled by the oscillated blood flow because VFP is driven at high frequency moving with short stroke volume.
振动血流泵（VFP）能够产生频率在10 - 40Hz之间的高频振荡血流。在本研究中，新型VFP被开发用作心室辅助装置。使用山羊进行了无菌动物实验，采用VFP进行左心室辅助循环。在清醒状态下连续记录血流动力学参数。VFP的驱动频率为25Hz，泵流速控制在约2升/分钟。VFP的频率为25Hz，泵流速控制在约2升/分钟。采用频率分析方法分析血流动力学。从血流波形的傅里叶变换中观察到功率峰值出现在25Hz。使用振荡血流开始左心室辅助后，全身血管阻力降低。在本研究期间未观察到致命性心律失常。结论是，新型VFP具有足够的左心室辅助性能。由于VFP以高频驱动且冲程量短，振荡血流可能使小型血泵成为可能。
