Erina E V, Basishvili N Z, Elizarova N A, Kheĭmets G I
Kardiologiia. 1976 Jul;16(7):82-7.
The haemodynamic parameters were studied dynamically by way of noninvasive techniques--tetrapolar thoracic rheography in the course of treatment of 48 patients with essential hypertension Stage IB and IIA urth beta-blocking agents Obsidan and Visken. It was found that as early as by the 5th day of therapy the stroke volume and heart rate decreased, the maximum fall being noted after 2-3 weeks of treatment. The reflex elevation of the total peripheral resistance was moderate, as a result of which a gradual reduction of the arterial pressure developed. The state of the cerebral circulation significantly improved in the course of the treatment (as shown by rheoencephalography) and the tone of the cerebral arteries decreased. After 2-3 weeks of beta-blockers therapy favourable shifts were observed in the response of the general and cerebral haemodynamics to the orthostatic test.
采用无创技术——四极胸血流图，动态研究了48例ⅠB期和ⅡA期原发性高血压患者在使用β受体阻滞剂奥昔地平和吲哚洛尔治疗过程中的血流动力学参数。结果发现，早在治疗第5天，每搏输出量和心率就开始下降，治疗2 - 3周后下降最为明显。总外周阻力的反射性升高较为适度，从而使动脉压逐渐降低。在治疗过程中，脑循环状态显著改善（脑血流图显示），脑动脉张力降低。β受体阻滞剂治疗2 - 3周后，全身和脑血流动力学对直立试验的反应出现了有利变化。
