Hassan A M, Keene D L, Whiting S E, Jacob P J, Champagne J R, Humphreys P
Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Pediatr Neurol. 1999 Aug;21(2):548-52. doi: 10.1016/s0887-8994(99)00045-4.
There has been renewed interest in the ketogenic diet in the treatment of medically refractory seizure disorders in childhood. This article reports the results of a retrospective chart review of 52 patients who were treated with the ketogenic diet. The vast majority (49 of 52) were treated with the classic 4:1 diet. Seizure control improved in 67.3% of patients with complete abolition of seizures in six. Adverse reactions were uncommon and included the development of renal stones, gall bladder stones, and hypoproteinemia in one patient each. Routine biochemical screening during the diet did not identify or prevent adverse events. The authors' experiences with the diet emphasize the need for close ongoing medical and dietary supervision.
生酮饮食在治疗儿童难治性癫痫疾病方面再次引起了人们的关注。本文报告了对52例接受生酮饮食治疗的患者进行回顾性病历审查的结果。绝大多数（52例中的49例）采用经典的4:1饮食进行治疗。67.3%的患者癫痫得到控制，其中6例癫痫完全消失。不良反应并不常见，分别有1例患者出现肾结石、胆结石和低蛋白血症。饮食期间的常规生化筛查未能识别或预防不良事件。作者在饮食方面的经验强调了持续密切的医疗和饮食监督的必要性。
