Takasaki M, Tsurumi N, Harada M, Rokugo N, Arai H, Katsunuma H, Ebihara Y, Wakasugi K
Department of Gerontology, Tokyo Medical University.
Nihon Ronen Igakkai Zasshi. 1999 May;36(5):323-7. doi: 10.3143/geriatrics.36.323.
An important background characteristic of anemia in the elderly is decrease in hematopoiesis due to aging. Factors influencing hematopoiesis in the elderly include changes in the distribution of hematopoietic tissue, changes in hematopoietic stem cell density and changes in the hematopoietic inductive microenvironment. In the present study, in order to assess changes in the bone marrow with aging, the fat tissue area, uncleated cell-count and cellularity in the bone marrow, in addition to changes in the diameter of the vascular lumen which result primarily from sclerotic changes in the dorsomedial artery of the bone marrow were determined in different age groups. The results revealed that all of the aforementioned factors changed significantly with aging. We also describe on the results of assays of inflammatory cytokines (IL-1, IL-6, TNF-alpha), lactoferrin and transferrin receptors in cases of anemia of chronic disorders (ACD) which own secondary to chronic inflammatory diseases and is known to frequently afflict the elderly.
老年人贫血的一个重要背景特征是由于衰老导致造血功能下降。影响老年人造血功能的因素包括造血组织分布的变化、造血干细胞密度的变化以及造血诱导微环境的变化。在本研究中，为了评估骨髓随年龄的变化，除了主要由骨髓背内侧动脉硬化变化导致的血管腔直径变化外，还测定了不同年龄组骨髓中的脂肪组织面积、未成熟细胞计数和细胞密度。结果显示，上述所有因素均随年龄发生显著变化。我们还描述了慢性疾病性贫血（ACD）患者炎症细胞因子（IL-1、IL-6、TNF-α）、乳铁蛋白和转铁蛋白受体的检测结果，慢性疾病性贫血继发于慢性炎症性疾病，且已知常困扰老年人。
