Piéroni L, Foglietti M J, Andreux J P, Albou D, Nafziger J
Laboratoire d'Hématologie Cellulaire et Moléculaire, Université René Descartes, Paris, France.
Gerontology. 1997;43(6):326-34. doi: 10.1159/000213872.
Erythropoietin secretion was evaluated in the anaemia of chronic disorders in elderly patients, since it has been shown that this secretion is impaired in adults. We looked for a possible role of inflammatory cytokines: tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on erythropoietin production. The influence of nutritional status on the anaemia was also investigated. Erythropoietin secretion was significantly increased in elderly patients with anaemia of chronic disorders (ACD) and inversely correlated with haemoglobin concentrations in infectious and inflammatory diseases. Plasma TNF alpha levels were significantly enhanced only in cancerous patients, but no correlation could be established between TNF alpha and erythropoietin or haemoglobin. No noticeable increase of IL-1 beta levels was observed in ACD. These findings suggest that systemic TNF alpha or IL-1 beta are not involved in the erythropoietin response to ACD. Albumin levels were decreased in anaemic patients. Further investigations of the effects of a nutritional supplementation in elderly patients with ACD may be of interest.
对老年患者慢性疾病性贫血中的促红细胞生成素分泌进行了评估，因为已有研究表明成人的这种分泌会受损。我们探究了炎性细胞因子：肿瘤坏死因子-α（TNFα）和白细胞介素-1β（IL-1β）对促红细胞生成素产生的可能作用。还研究了营养状况对贫血的影响。慢性疾病性贫血（ACD）老年患者的促红细胞生成素分泌显著增加，且在感染性和炎性疾病中与血红蛋白浓度呈负相关。仅癌症患者的血浆TNFα水平显著升高，但TNFα与促红细胞生成素或血红蛋白之间未发现相关性。在ACD患者中未观察到IL-1β水平有明显升高。这些发现表明全身性TNFα或IL-1β不参与对ACD的促红细胞生成素反应。贫血患者的白蛋白水平降低。进一步研究营养补充对老年ACD患者的影响可能会有意义。
