Magálová T, Bella V, Brtková A, Beno I, Kudlácková M, Volkovová K
Research Institute of Nutrition, Bratislava, Slovak Republic.
Neoplasma. 1999;46(2):100-4.
The aim of the present study was to assess serum levels of copper and zinc levels and erythrocytes Cu,Zn-SOD activity and to determine probable changes in gastric and colorectal precancerous diseases, benign breast diseases, gastric, colorectal and breast cancer. The study included 165 subjects with cancer, 348 subjects with precancerous (atrophic gastritis, gastric adenoma, colon adenoma, rectal adenoma) and/or benign diseases (weak dysplasia, severe dysplasia, fibroadenoma, cystic disease) and 161 randomly selected healthy controls. Our results suggest that while in gastric and colorectal cancer there were mostly increased copper levels, in breast cancer they were not changed. Zinc levels were weakly decreased in atrophic gastritis, gastric adenoma and breast cancer. There was a strong positive correlation between zinc levels and SOD activity in fibroadenoma and a weak positive correlation in colorectal adenoma and colorectal cancer without any correlation between SOD activity and copper in these groups. In gastric precancerous disease there was a positive correlation between SOD and copper. The results of this study suggest that serum trace element levels and activity of related enzymes might be different in various neoplastic processes. This variation in neoplastic processes might be influenced by other factors that have to be considered in complex relationships between the whole body and neoplastic cells.
本研究的目的是评估血清铜和锌水平以及红细胞铜锌超氧化物歧化酶（Cu,Zn-SOD）活性，并确定胃癌、结直肠癌癌前疾病、乳腺良性疾病、胃癌、结直肠癌和乳腺癌中可能存在的变化。该研究纳入了165例癌症患者、348例患有癌前疾病（萎缩性胃炎、胃腺瘤、结肠腺瘤、直肠腺瘤）和/或良性疾病（轻度发育异常、重度发育异常、纤维腺瘤、囊性疾病）的患者以及161例随机选取的健康对照者。我们的结果表明，胃癌和结直肠癌患者的铜水平大多升高，而乳腺癌患者的铜水平未发生变化。萎缩性胃炎、胃腺瘤和乳腺癌患者的锌水平略有下降。纤维腺瘤中锌水平与SOD活性呈强正相关，结直肠腺瘤和结直肠癌中呈弱正相关，且这些组中SOD活性与铜之间无相关性。胃癌前疾病中SOD与铜呈正相关。本研究结果表明，血清微量元素水平和相关酶活性在不同的肿瘤发生过程中可能存在差异。肿瘤发生过程中的这种变化可能受到其他因素的影响，在全身与肿瘤细胞之间的复杂关系中必须考虑这些因素。
