Lin Yulan, Wu Chuancheng, Yan Wei, Guo Saixiong, Liu Baoying
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, Fujian, People's Republic of China.
Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Cancer Manag Res. 2020 Jun 10;12:4441-4451. doi: 10.2147/CMAR.S250592. eCollection 2020.
Serum trace elements have for some time been suggested to influence the development of gastric cancer, but evidence is still lacking.
All newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (±3 years), and place of residence during 2013-2015. The serum concentration of all trace elements was analyzed using inductively coupled plasma mass spectrometry. infections in cases were diagnosed using the rapid urease test, while in controls were detected using the colloidal gold method.
A total of 122 cases of gastric cardia cancer (GCC) and 177 gastric noncardia cancer (NCGC), and 299 matched healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR: 2.42, 95% CI: 1.10-5.32 for copper; OR: 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio), and for both GCC and NCGC subtypes. Serum selenium was inversely associated with the risk of NCGC (OR: 0.18, 95% CI: 0.07-0.51), while molybdenum seems to reduce the risk of GCC (OR: 0.12, 95% CI: 0.03-0.47). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all for trend<0.05).
The current study indicated statistically significant positive associations between serum copper, copper/zinc ratio, and gastric cancer, as well as inverse associations among selenium, molybdenum, and calcium. The results shall be carefully interpreted before further in vivo animal studies show definitive evidence.
一段时间以来，有观点认为血清微量元素会影响胃癌的发生发展，但仍缺乏相关证据。
在2013年至2015年期间，将所有新诊断的胃癌患者与按性别、年龄（±3岁）和居住地1:1匹配的健康对照进行比较。使用电感耦合等离子体质谱法分析所有微量元素的血清浓度。病例组的感染采用快速尿素酶试验诊断，对照组采用胶体金法检测。
共纳入122例贲门胃癌（GCC）、177例非贲门胃癌（NCGC）以及299例匹配的健康对照。血清铜、铜/锌比值与总体胃癌风险之间呈正相关（铜：OR = 2.42，95%CI：1.10 - 5.32；铜/锌比值：OR = 11.7，95%CI：3.83 - 35.6），GCC和NCGC亚型均如此。血清硒与NCGC风险呈负相关（OR = 0.18，95%CI：0.07 - 0.51），而钼似乎可降低GCC风险（OR = 0.12，95%CI：0.03 - 0.47）。血清钙与所有胃癌组的风险之间也存在强负相关（所有趋势检验P<0.05）。
本研究表明血清铜、铜/锌比值与胃癌之间存在统计学显著的正相关，以及硒、钼和钙之间存在负相关。在进一步的体内动物研究提供确凿证据之前，对这些结果应谨慎解读。
