Kode Manasi Ankolekar, Karjodkar Freny Rashmiraj
Reader, Department of Oral Medicine & Radiology, Shri Aurobindo College of Dentistry , Indore, Madhya Pradesh, India .
J Clin Diagn Res. 2013 Jun;7(6):1215-8. doi: 10.7860/JCDR/2013/5207.3023. Epub 2013 Jun 1.
Gutkha packets contain trace elements like copper, zinc, iron and magnesium. This study compared the levels of the trace elements in patients with gutkha eating habits with or without oral submucous fibrosis and in healthy patients.
A total of 75 patients were included in this study and they were divided into three groups; the individuals with a history of gutkha intake with OSMF, the individuals with a history of gutkha intake without OSMF and apparently healthy individuals without OSMF and without any habits. Blood and saliva was collected and they were subjected for analysis by using atomic absorption spectrometry and a differential pulse anodic stripping voltmeter.
The results were tabulated and they were subjected to a statistical analysis.
There was a significant difference in the serum Mg and Fe levels between the patients with habits and the normal healthy individuals. A significant difference was observed in the serum zinc levels in the patients with habits with and without OSMF. Altered serum trace element levels are documented in malignant cases and they are considered to be good biomarkers for malignancies. The serum copper and Zn levels and the Cu/Zn ratio in OSMF patients can be considered as the markers which show a susceptibility towards cancer.
古特卡包装中含有铜、锌、铁和镁等微量元素。本研究比较了有或无口腔黏膜下纤维化的有古特卡饮食习惯的患者以及健康患者体内微量元素的水平。
本研究共纳入75名患者，他们被分为三组；有口腔黏膜下纤维化且有古特卡摄入史的个体、有古特卡摄入史但无口腔黏膜下纤维化的个体以及无口腔黏膜下纤维化且无任何习惯的明显健康个体。采集血液和唾液，并使用原子吸收光谱法和差分脉冲阳极溶出伏安仪对其进行分析。
将结果制成表格并进行统计分析。
有习惯的患者与正常健康个体之间血清镁和铁水平存在显著差异。在有和无口腔黏膜下纤维化的有习惯的患者中，血清锌水平观察到显著差异。恶性病例中记录了血清微量元素水平的改变，它们被认为是恶性肿瘤的良好生物标志物。口腔黏膜下纤维化患者的血清铜和锌水平以及铜/锌比值可被视为显示对癌症易感性的标志物。
