人脑代谢物的质子磁化转移

Proton magnetization transfer of metabolites in human brain.

作者信息

Meyerhoff D J

机构信息

Magnetic Resonance Unit, Department of Veterans Affairs Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California, USA.

出版信息

Magn Reson Med. 1999 Sep;42(3):417-20. doi: 10.1002/(sici)1522-2594(199909)42:3<417::aid-mrm1>3.0.co;2-t.

DOI:10.1002/(sici)1522-2594(199909)42:3<417::aid-mrm1>3.0.co;2-t

PMID:10467283

Abstract

Off-resonance or pulsed on-resonance saturation pulses were used together with localized proton magnetic resonance spectroscopy in three brain regions of 20 healthy individuals. Statistically significant signal attenuations were observed for creatine-containing metabolites in posterior-parietal brain (12%), basal ganglia (18%), and cerebellum (15%). N-acetyl- and choline-containing metabolites were not significantly attenuated upon application of saturation pulses in either brain region. The findings are interpreted to reflect possible magnetization transfer between pools of creatine-containing metabolites with different molecular mobility. Magn Reson Med 42:417-420, 1999.

摘要

在20名健康个体的三个脑区中，将非共振或脉冲共振饱和脉冲与局部质子磁共振波谱法结合使用。在后顶叶脑区（12%）、基底神经节（18%）和小脑（15%）中，观察到含肌酸代谢物的信号有统计学意义的衰减。在任一脑区施加饱和脉冲后，含N-乙酰基和胆碱的代谢物均未出现明显衰减。这些发现被解释为反映了具有不同分子流动性的含肌酸代谢物池之间可能存在的磁化转移。《磁共振医学》42:417 - 420, 1999年。