Sarcoma Disease Management Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Magn Reson Med. 2010 Mar;63(3):713-8. doi: 10.1002/mrm.22208.
An MRI technique is proposed for complete fat signal elimination. This approach exploits the fact that water rapidly exchanges magnetization with protons in protein and membrane phospholipid of tissue and cells but does not exchange magnetization with triglyceride or fat protons in the tissue. Saturation of the proton signal from protein and membrane phospholipid thus results in partial saturation of the water proton signal, allowing acquisition of an image including a portion of the water signal and the full fat signal. Subtraction of this image from the standard image, containing both water and fat signals, results in an image in which all fat signal is cancelled. This fat-free image is sensitive to magnetization transfer and to water density and relaxation time, providing the possibility of additional contrast. Unlike most fat suppression techniques, this method is not compromised by the static or radiofrequency field heterogeneity and is equally efficient for all fat resonances independent of their chemical shift frequency.
提出了一种用于完全消除脂肪信号的 MRI 技术。该方法利用了这样一个事实，即水与组织和细胞中的蛋白质和膜磷脂中的质子迅速交换磁化，但与组织中的甘油三酯或脂肪质子不交换磁化。因此，蛋白质和膜磷脂的质子信号的饱和导致水质子信号的部分饱和，从而允许获取包括一部分水信号和全部脂肪信号的图像。从包含水和脂肪信号的标准图像中减去该图像，得到其中所有脂肪信号都被消除的图像。这种无脂肪的图像对磁化转移以及水密度和弛豫时间敏感，提供了额外对比度的可能性。与大多数脂肪抑制技术不同，该方法不受静态或射频场非均匀性的影响，并且对所有脂肪共振都同样有效，与它们的化学位移频率无关。
