Filippi M, Tortorella C, Bozzali M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Milan, Italy.
Mult Scler. 1999 Aug;5(4):273-82. doi: 10.1177/135245859900500414.
Several magnetic resonance (MR) techniques have proved to be sensitive enough to detect the subtle pathological changes that post-mortem studies showed to occur in the normal-appearing white matter (NAWM) from patients with multiple sclerosis (MS). Although these abnormalities can be detected in other neurological conditions, they seem to be more frequent and diffuse in MS. However, the contribution of NAWM changes to the diagnosis is still unclear. Their nature is also unknown and perhaps differs in different phases and clinical manifestations of the disease. Nevertheless, the extent and severity of NAWM damage seems to be relevant in causing disability and influencing the clinical evolution in MS patients. This review will summarize the present knowledge about MR-detected NAWM changes in MS and their relevance to the diagnosis and the understanding of disease evolution.
几种磁共振（MR）技术已被证明足够灵敏，能够检测到尸检研究显示在多发性硬化症（MS）患者正常外观白质（NAWM）中发生的细微病理变化。尽管这些异常在其他神经系统疾病中也能被检测到，但在MS中似乎更频繁且更广泛。然而，NAWM变化对诊断的贡献仍不明确。其性质也未知，可能在疾病的不同阶段和临床表现中有所不同。尽管如此，NAWM损伤的程度和严重程度似乎与MS患者的残疾发生及临床进展相关。本综述将总结目前关于MS中MR检测到的NAWM变化及其与诊断和疾病进展理解的相关性的知识。
