Arrants J, Willis M E, Stevens B, Gripkey L, Herman J A, Hernandez-Brooks L, Eaker J E
Nursing Service, William Jennings Bryan Dorn Veterans Affairs Medical Center, Columbia, SC, USA.
Am J Crit Care. 1999 Sep;8(5):344-8.
Patients admitted to rule out myocardial infarction often receive a heparin infusion that requires measurement of partial thromboplastin time every 6 to 8 hours until coagulation values stabilize. If the patient's acuity at admission does not necessitate placement of arterial or central catheters, insertion of an intermittent intravenous access port (saline lock) would decrease the need for frequent venipuncture. Many studies on obtaining blood samples via arterial and central catheters have been reported, but no reports have described the method of using a saline lock or the amount of blood discarded during that procedure.
To evaluate the efficacy of inserting a saline lock specifically for obtaining blood samples and to determine the amount of blood that must be discarded in order to obtain prothrombin and partial thromboplastin times that match the values from blood samples obtained via venipuncture.
Coagulation values determined with 2 consecutive blood samples obtained via the saline lock after the first 0.5 mL of blood withdrawn was discarded were compared with measurements determined with a blood sample obtained via venipuncture.
Prothrombin and partial thromboplastin times were not significantly different among the 3 blood samples.
The untoward effects of frequent venipunctures to obtain blood samples for measurement of prothrombin and partial thromboplastin times can be lessened by using an 18-gauge saline lock to obtain blood samples and discarding the first 0.5 mL of blood withdrawn before the samples for coagulation studies are collected.
因排除心肌梗死而入院的患者常接受肝素输注,在此期间需要每6至8小时测量一次部分凝血活酶时间,直至凝血值稳定。如果患者入院时的病情严重程度不需要放置动脉导管或中心静脉导管,插入一个间歇性静脉输液港(生理盐水锁)将减少频繁静脉穿刺的需求。关于通过动脉导管和中心静脉导管采集血样的研究已有很多报道,但尚无关于使用生理盐水锁的方法或该过程中弃血量的报道。
评估专门为采集血样而插入生理盐水锁的有效性,并确定为获得与静脉穿刺采集的血样值相匹配的凝血酶原时间和部分凝血活酶时间必须弃去的血量。
在弃去最初抽取的0.5 mL血液后,比较通过生理盐水锁采集的连续两份血样所测定的凝血值与通过静脉穿刺采集的血样所测定的凝血值。
三份血样的凝血酶原时间和部分凝血活酶时间无显著差异。
通过使用18号生理盐水锁采集血样并在采集用于凝血研究的血样前弃去最初抽取的0.5 mL血液,可以减少因频繁静脉穿刺采集血样以测定凝血酶原时间和部分凝血活酶时间所带来的不良影响。