van Nielen K M, de Jong B M
Department of Neurology, University Hospital Groningen, The Netherlands.
Clin Neurol Neurosurg. 1999 Jun;101(2):106-10. doi: 10.1016/s0303-8467(98)00072-9.
Ollier's disease, or multiple enchondromatosis, is a deforming dysplastic disease of cartilage, characterized by multiple, asymmetrically distributed intra-osseous cartilaginous masses in the metaphyses and diaphyses of bones. When associated with soft tissue hemangiomas it is referred to as Maffucci's syndrome, in which the enchondromatosis has no unilateral distribution. The emergence of malignant neoplasms, including gliomas, is a well-recognized complication in Maffucci's syndrome. We report a 28-year-old patient with a history of Ollier's disease, who developed two low-grade cerebral gliomas as well as an intracranial chondroma. This case history questions the distinction between the two forms of enchondromatosis and supports a continuum between these disease entities.
奥利尔病，即多发性内生软骨瘤病，是一种软骨发育异常性疾病，其特征为在骨的干骺端和骨干中存在多个不对称分布的骨内软骨肿块。当与软组织血管瘤相关联时，它被称为马富西综合征，其中内生软骨瘤病没有单侧分布。包括胶质瘤在内的恶性肿瘤的出现是马富西综合征中一种公认的并发症。我们报告一名28岁有奥利尔病病史的患者，其发生了两个低级别脑胶质瘤以及一个颅内软骨瘤。该病例病史对两种内生软骨瘤病形式之间的区别提出了质疑，并支持这些疾病实体之间存在连续性。
