Loimaranta V, Laine M, Söderling E, Vasara E, Rokka S, Marnila P, Korhonen H, Tossavainen O, Tenovuo J
Institute of Dentistry and Turku Immunology Centre, University of Turku, Finland.
Eur J Oral Sci. 1999 Aug;107(4):244-50. doi: 10.1046/j.0909-8836.1999.eos107403.x.
Colostral products from non-immunized cows (CP) and cows immunized with mutans streptococci (IP) were used as mouth rinses in a short-term human study. The acidogenic potential of the products was tested and found to be negligible in vivo before application to subsequent rinsing tests. At first, all the participants received a professional tooth cleaning, after which they rinsed with one of the solutions (IP; CP; water) three times per day for 3 d. After each rinsing period, the resting pH and decrease in plaque pH after sucrose challenge were determined, the amount of plaque was estimated, and all available plaque was collected. No significant differences were recorded in the composition or in the amounts of accumulated plaque. The resting pH values of plaques with low "innate" pH were increased after the IP rinsing period. Surprisingly, the lowest pH values after the sucrose challenge were recorded in IP plaques. The number of cultivable facultative flora or total streptococci were not affected by different rinsings, but the relative number of mutans streptococci significantly decreased after the IP rinsing period when compared to the CP period. Thus, the short term rinsing indicates favourable effects of bovine immune whey on human dental plaque.
在一项短期人体研究中，将未免疫奶牛的初乳产品（CP）和用变形链球菌免疫的奶牛的初乳产品（IP）用作漱口水。测试了这些产品的产酸潜力，发现在用于后续冲洗测试之前，其体内产酸潜力可忽略不计。首先，所有参与者都接受了专业的牙齿清洁，之后他们每天用其中一种溶液（IP；CP；水）漱口3次，共3天。在每个漱口期后，测定静息pH值和蔗糖激发后菌斑pH值的下降，估计菌斑量，并收集所有可用的菌斑。在菌斑组成或积累量方面未记录到显著差异。低“固有”pH值的菌斑在IP漱口期后的静息pH值有所升高。令人惊讶的是，蔗糖激发后最低的pH值出现在IP菌斑中。不同漱口方式对可培养兼性菌群或总链球菌数量没有影响，但与CP期相比，IP漱口期后变形链球菌的相对数量显著减少。因此，短期漱口表明牛免疫乳清对人类牙菌斑有有利影响。
