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胆红素作为手术应激的抗氧化剂：胆红素氧化代谢产物的初步报告

Bilirubin as an anti-oxidant for surgical stress: a preliminary report of bilirubin oxidative metabolites.

作者信息

Kozaki N, Shimizu S, Chijiiwa K, Yamaguchi K, Kuroki S, Shimoharada K, Yamaguchi T, Nakajima H, Tanaka M

机构信息

First Department of Surgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.

出版信息

HPB Surg. 1999;11(4):241-8. doi: 10.1155/1999/16374.

DOI:10.1155/1999/16374
PMID:10468115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2423980/
Abstract

BACKGROUND

Bilirubin has been recognized as an anti-oxidant. The purpose of this study was to examine whether bilirubin would act as an antioxidant for surgical stress in humans.

MATERIALS AND METHODS

Serum bilirubin and urinary bilirubin oxidative metabolites (BOM) were measured in 96 patients who underwent surgery. The antioxidant activity of bilirubin was assessed using BOM measured by enzyme-linked immunosorbent assay with an anti-bilirubin monoclonal antibody.

RESULTS

Serum bilirubin levels increased after surgery in all 96 patients (p < 0.01), but did not correlate with operation time or blood loss (p = 0.53 and p = 0.28, respectively). BOM increased only in patients with major surgeries (p = 0.048). Significant correlations between BOM and operation time and blood loss were found (p < 0.01).

CONCLUSIONS

Bilirubin appears to act as an antioxidant for invasive surgery in humans. Urinary BOM could be a reliable marker for the degree of surgical stress.

摘要

背景

胆红素已被公认为一种抗氧化剂。本研究的目的是检验胆红素是否会作为人体手术应激的抗氧化剂。

材料与方法

对96例接受手术的患者测定血清胆红素和尿胆红素氧化代谢产物（BOM）。使用通过抗胆红素单克隆抗体的酶联免疫吸附测定法测量的BOM评估胆红素的抗氧化活性。

结果

所有96例患者术后血清胆红素水平均升高（p < 0.01），但与手术时间或失血量无关（分别为p = 0.53和p = 0.28）。仅在接受大手术的患者中BOM升高（p = 0.048）。发现BOM与手术时间和失血量之间存在显著相关性（p < 0.01）。

结论

胆红素似乎可作为人体侵入性手术的抗氧化剂。尿BOM可能是手术应激程度的可靠标志物。