Yousefi Maryam, Rahimi Hoda, Barikbin Behrooz, Toossi Parviz, Lotfi Sara, Hedayati Mehdi, Younespour Shima
Skin Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti Medical University, Tehran, Iran.
Indian J Dermatol. 2011 May;56(3):278-81. doi: 10.4103/0019-5154.82480.
Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, and alopecia areata. ROS has an important role in the inflammation process. In PV, increased production of ROS leads to decline of antioxidants in plasma and red blood cells which results in oxidative stress. We aimed to evaluate the level of these antioxidants in PV patients and compare it to the controls.
Among patients attending the dermatology clinics, 30 patients with PV, who had never been on treatment, were enrolled to the study. The control group consisted of 30 age- and sex-matched healthy non-smoker individuals. Venous blood was collected from the subjects for the evaluation of plasma levels of glutathione peroxidase, vitamin C, selenium, bilirubin, and uric acid.
Age mean and standard deviation of the patients (40.83, 12.74) was comparable to the controls (41.96, 13.08). Mean level of uric acid was significantly lower in PV patients compared to the controls (P = 0.006). Other antioxidants were not different between the two groups. Uric acid of the patients with mucosal involvement was significantly lower than patients with mucocutaneous involvement (P = 0.049).
The blood level of other antioxidants (e.g. malondialdehyde) was not evaluated.
Uric acid as an antioxidant in our study had similar changes to previous studies in the field of other diseases but selenium, bilirubin, and glutathione peroxidase did not differ between patients and controls.
在许多皮肤病中都可见活性氧（ROS）增加和脂质过氧化，例如特应性皮炎、银屑病、白癜风、寻常痤疮、寻常型天疱疮（PV）、扁平苔藓和斑秃。ROS在炎症过程中起重要作用。在PV中，ROS产生增加导致血浆和红细胞中抗氧化剂减少，从而导致氧化应激。我们旨在评估PV患者中这些抗氧化剂的水平，并与对照组进行比较。
在皮肤科门诊就诊的患者中，选取30例从未接受过治疗的PV患者纳入研究。对照组由30名年龄和性别匹配的健康非吸烟者组成。采集受试者静脉血，以评估血浆中谷胱甘肽过氧化物酶、维生素C、硒、胆红素和尿酸的水平。
患者的年龄均值和标准差（40.83，12.74）与对照组（41.96，13.08）相当。与对照组相比，PV患者的尿酸平均水平显著降低（P = 0.006）。两组间其他抗氧化剂无差异。黏膜受累患者的尿酸水平显著低于黏膜皮肤受累患者（P = 0.049）。
未评估其他抗氧化剂（如丙二醛）的血液水平。
在我们的研究中，尿酸作为一种抗氧化剂，其变化与该领域其他疾病的先前研究相似，但患者与对照组之间的硒、胆红素和谷胱甘肽过氧化物酶无差异。
