Tabuchi T, Ubukata H, Saniabadi A R, Soma T
Department of Surgery, Kasumigaura Hospital, Tokyo Medical College, Ibaragi, Japan.
Cancer Detect Prev. 1999;23(5):417-21. doi: 10.1046/j.1525-1500.1999.99029.x.
Patients with advanced cancer often develop immunodeficiency which may be associated with granulocytosis. The granulocytes have the potential to deplete cytotoxic T cells, resulting in accelerated tumor growth and metastasis. To study the elimination of excess granulocytes using granulocyte apheresis in patients with elevated granulocyte to lymphocyte ratios, 2 patients with recurrent metastatic tumors, were selected. Granulocyte apheresis was performed by extracorporeal vein-to-vein circulation with the G-1 granulocyte and monocyte/macrophage apheresis column filled with cellulose acetate beads, each 2 mm in diameter to adsorb granulocytes and monocytes/macrophages. The patients received 1 or 2 apheresis of 30 to 50 min duration per week, at a flow rate of 30-50 ml/min, with 15 sessions constituting one therapeutic course. Apheresis markedly reduced tumor size and prolonged patient survival time without causing any serious adverse events. The results of the present study suggest that granulocyte and monocyte/macrophage apheresis may be beneficial in patients with metastasizing tumors.
晚期癌症患者常出现免疫缺陷，这可能与粒细胞增多有关。粒细胞有可能消耗细胞毒性T细胞，导致肿瘤生长和转移加速。为了研究在粒细胞与淋巴细胞比例升高的患者中使用粒细胞单采术清除多余粒细胞的效果，选择了2例复发性转移性肿瘤患者。通过体外静脉到静脉循环，使用填充有直径为2毫米醋酸纤维素珠的G-1粒细胞和单核细胞/巨噬细胞单采柱进行粒细胞单采，以吸附粒细胞和单核细胞/巨噬细胞。患者每周接受1或2次持续30至50分钟的单采，流速为30-50毫升/分钟，15次疗程为一个治疗疗程。单采术显著缩小了肿瘤大小并延长了患者生存时间，且未引起任何严重不良事件。本研究结果表明，粒细胞和单核细胞/巨噬细胞单采术可能对转移性肿瘤患者有益。
