Tabuchi T, Ubukata H, Sato S, Nakata I, Goto Y, Watanabe Y, Hashimoto T, Mizuta T, Adachi M, Soma T
Department of Surgery, Kasumigaura Hospital, Tokyo Medical College, Ibaragi, Japan.
Anticancer Res. 1995 May-Jun;15(3):985-90.
We assessed the effect of granulocyte apheresis in patients exhibiting increased granulocyte-to-lymphocyte ratio in order to overcome granulocytosis occurring in the terminal stages of malignancies. 17 patients with post-operative recurrent metastatic tumors including 6 gastric, 3 colonic, 2 rectal, 1 esophageal and 5 breast cancers were selected. The granulocytapheresis was performed by extracorporeal vein-to-vein circulation equipped with an apheresis column filled with cellulose acetate beads. Each week the patients underwent one or two sessions of treatment that lasted 30 to 50 minutes per session at a flow rate of 30 to 50 ml/min. 15 sessions formed 1 therapeutic cycle. The effect of granulocytapheresis resulted in partial response (PR) in 4 cases, no change (NC) in 7 cases and partial disease (PD) in 6 cases. The performance status showed 30% remission. None of the patients exhibited significant side effects. Since the treatment demonstrated anti-tumor effects, granulocytapheresis may be applied during combined cancer treatments.
我们评估了粒细胞单采术对粒细胞与淋巴细胞比值升高患者的影响，以克服恶性肿瘤终末期出现的粒细胞增多症。选取了17例术后复发性转移性肿瘤患者，其中包括6例胃癌、3例结肠癌、2例直肠癌、1例食管癌和5例乳腺癌。粒细胞单采术通过配备装有醋酸纤维素珠的单采柱的体外静脉到静脉循环进行。患者每周接受一或两次治疗，每次治疗持续30至50分钟，流速为30至50毫升/分钟。15次治疗构成1个治疗周期。粒细胞单采术的效果为4例部分缓解（PR），7例无变化（NC），6例疾病进展（PD）。体能状态显示30%缓解。所有患者均未出现明显副作用。由于该治疗显示出抗肿瘤作用，粒细胞单采术可在联合癌症治疗期间应用。
