Conrad N, Jackson B, Goldberg L
Department of Dermatology, Baylor College of Medicine, Texas, USA.
Dermatol Surg. 1999 May;25(5):408-11. doi: 10.1046/j.1524-4725.1999.08271.x.
Amelanotic melanomas comprise only 2% of melanomas and are commonly a difficult clinical diagnosis, due to the lack of melanin pigment typically found in melanomas. Even rarer is the amelanotic lentigo maligna, which may have an unusual clinical presentation, such as erythema, pruritus, or edema. Biopsy is the key to diagnosis. Multiple therapies for amelanotic lentigo malignas have been tried, but excision, with margin control (Mohs micrographic surgery-frozen or paraffin sections), remains the treatment of choice.
无色素性黑色素瘤仅占黑色素瘤的2%，由于缺乏黑色素瘤中通常存在的黑色素，临床上通常难以诊断。更为罕见的是无色素性恶性雀斑样痣，其临床表现可能不寻常，如红斑、瘙痒或水肿。活检是诊断的关键。已尝试多种治疗无色素性恶性雀斑样痣的方法，但切除并控制切缘（莫氏显微外科手术——冰冻切片或石蜡切片）仍是首选治疗方法。
