Brown T J, Tschen J A
St. Joseph Hospital, Houston, Texas, USA.
Dermatol Surg. 1999 Jun;25(6):498-500. doi: 10.1046/j.1524-4725.1999.08219.x.
Carcinosarcoma is a biphasic tumor composed of intimately admixed epithelial and mesenchymal elements, both of which are malignant. Primary cutaneous involvement is extremely rare. Therefore it has been difficult to characterize the clinical course of carcinosarcoma of the skin.
To describe a further case of carcinosarcoma of the skin and to provide a review of the literature.
The clinical records of the patient and histopathology of the neoplasm are reviewed. In addition, the results of all previously reported cases of carcinosarcoma of the skin are compiled for reexamination.
After complete excision of the carcinosarcoma, the patient shows no evidence of disease for 9 months. Long-term follow-up is needed because of the risk of recurrence or metastasis that may occur with this neoplasm.
Carcinosarcoma of the skin appears to be associated with a good prognosis when compared with similar tumors located elsewhere. Metastasis (with or without documented mortality) has been reported in 3 of 16 patients (16.7%). Death from local disease has been reported in one additional patient (6.3%). However, further cases with long-term follow-up are needed in order to better understand the nature of this cutaneous neoplasm.
癌肉瘤是一种双相性肿瘤，由紧密混合的上皮和间充质成分组成，二者均为恶性。原发性皮肤受累极为罕见。因此，很难描述皮肤癌肉瘤的临床病程。
描述另一例皮肤癌肉瘤病例并对文献进行综述。
回顾患者的临床记录和肿瘤的组织病理学。此外，汇总所有先前报道的皮肤癌肉瘤病例的结果以供重新审视。
癌肉瘤完全切除后，患者9个月无疾病迹象。由于该肿瘤可能发生复发或转移的风险，需要进行长期随访。
与其他部位的类似肿瘤相比，皮肤癌肉瘤似乎预后良好。16例患者中有3例（16.7%）报告发生转移（有或无记录的死亡）。另有1例患者（6.3%）报告死于局部疾病。然而，需要更多长期随访的病例，以便更好地了解这种皮肤肿瘤的性质。
