皮肤癌肉瘤：6例病例系列报道及文献综述
Cutaneous carcinosarcoma: a series of six cases and a review of the literature.
作者信息
Clark Joshua J, Bowen Anneli R, Bowen Glen M, Hyngstrom John R, Hadley Michael L, Duffy Keith, Florell Scott R, Wada David A
机构信息
Department of Dermatology, University of Utah, Salt Lake City, UT, USA.
Department of Dermatology, Huntsman Cancer Institute, Salt Lake City, UT, USA.
出版信息
J Cutan Pathol. 2017 Jan;44(1):34-44. doi: 10.1111/cup.12843. Epub 2016 Nov 18.
BACKGROUND
Cutaneous carcinosarcoma is a rare tumor with distinct malignant epithelial and mesenchymal cell populations. The histologic subtypes of epithelial and mesenchymal components in cutaneous carcinosarcoma are variable, as an assortment of carcinomatous and sarcomatous patterns have been described in the literature.
METHODS
Clinical information was obtained from patient charts and archival slides were retrieved and reviewed.
RESULTS
We present a novel series of six distinct cases of cutaneous carcinosarcoma and review the literature. Our cases consisted of basal cell, pilomatrical, squamous cell, and trichoblastic variants. These cases occurred in elderly men on sun exposed skin with treatment and follow up was available for 4 of 6 cases. The four cases were treated with Mohs micrographic surgery with mean follow up of nine months.
CONCLUSION
We report six cases of cutaneous carcinosarcoma with distinctive clinical and histologic characterization not previously described in a single series.
背景
皮肤癌肉瘤是一种罕见肿瘤，具有明显的恶性上皮和间充质细胞群。皮肤癌肉瘤上皮和间充质成分的组织学亚型各不相同，因为文献中已描述了各种癌性和肉瘤性模式。
方法
从患者病历中获取临床信息，并检索和复查存档切片。
结果
我们报告了一系列6例不同的皮肤癌肉瘤新病例并复习文献。我们的病例包括基底细胞型、毛母质型、鳞状细胞型和毛母细胞型变体。这些病例发生在暴露于阳光下皮肤的老年男性身上，6例中有4例有治疗及随访情况。这4例接受了莫氏显微外科手术治疗，平均随访9个月。
结论
我们报告了6例皮肤癌肉瘤，其具有独特的临床和组织学特征，此前尚未在单个系列中描述过。
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