Bloemendal H J, Logtenberg T, Voest E E
Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
Eur J Clin Invest. 1999 Sep;29(9):802-9. doi: 10.1046/j.1365-2362.1999.00534.x.
Angiogenesis is a critical step in the progression of tumours from dormancy to a clinical relevant cancer. Inhibition of this process is one of the most promising new anti-cancer strategies. To develop new drugs that interfere with the cascade of events required for the formation of new blood vessels, insight into this process is essential. Here, we discuss the molecular basis of angiogenesis and the concepts of vascular targeting. Furthermore new strategies will be discussed to discover surface markers on endothelial cells that confer sufficient specificity for targeted intervention in the tumour vasculature.
血管生成是肿瘤从休眠状态发展为临床相关癌症过程中的关键步骤。抑制这一过程是最有前景的新型抗癌策略之一。要开发能够干扰新血管形成所需一系列事件的新药，深入了解这一过程至关重要。在此，我们将探讨血管生成的分子基础以及血管靶向的概念。此外，还将讨论用于发现内皮细胞表面标志物的新策略，这些标志物可为肿瘤脉管系统的靶向干预提供足够的特异性。
