Ramesh V, Misra R S, Beena K R, Mukherjee A
Department of Dermatology and Venereology and Institute of Pathology (ICMR), Safdarjang Hospital, New Delhi, India.
Pediatr Dermatol. 1999 Jul-Aug;16(4):264-9. doi: 10.1046/j.1525-1470.1999.00073.x.
Sixty-three children out of a total of 199 patients seen with cutaneous tuberculosis during a 7-year period were included in this study. Culture was positive in only four, and the diagnosis was based on clinical examination, tuberculin reaction, histopathology, and response to antitubercular therapy. Forty had lupus vulgaris (LV) and 23 scrofuloderma (SD). The lower half of the body was predominantly affected in those with LV, and keratotic and hypertrophic forms were frequently encountered. LV planus mainly affected the face. Ulcerative and atrophic types of LV were infrequent. Extensive lesions in three children led to disfiguring scars and contractures. Scrofuloderma often involved the cervical group of lymph nodes followed by the inguinal, submandibular, and axillary groups. As compared to skin tuberculosis in adults, regional lymph node involvement in LV was more common, and a combination of both LV and SD was less frequent in children. No difference in clinical presentation could be detected between the BCG vaccinated and unvaccinated children. Tuberculous infection either in the lungs or the bones was present in eight children. An HIV test done in five patients with widespread lesions was negative. Irregular therapy or late diagnosis leading to serious complications, inadequate parental or community support, and lack of awareness among practitioners are the problems to be remedied.
在7年期间诊治的199例皮肤结核患者中,63例儿童纳入本研究。仅4例培养结果为阳性,诊断基于临床检查、结核菌素反应、组织病理学及抗结核治疗反应。40例为寻常狼疮(LV),23例为瘰疬性皮肤结核(SD)。LV患者身体下半部受累为主,常出现角化型和肥厚型。扁平型LV主要累及面部。溃疡性和萎缩型LV少见。3例儿童广泛病变导致毁容性瘢痕和挛缩。瘰疬性皮肤结核常累及颈部淋巴结组,其次为腹股沟、颌下和腋窝淋巴结组。与成人皮肤结核相比,LV中区域淋巴结受累更常见,儿童中LV和SD合并出现较少见。接种卡介苗和未接种卡介苗的儿童临床表现无差异。8例儿童存在肺部或骨骼结核感染。对5例广泛病变患者进行的HIV检测为阴性。不规则治疗或诊断延迟导致严重并发症、家长或社区支持不足以及从业者认识不足是有待解决的问题。