Wang Y, Tao L, Mitchell E, Bravery C, Berlingieri P, Armstrong P, Vaughan R, Underwood J, Lehner T
Department of Immunobiology, Guy's, King's and St. Thomas' Medical and Dental Schools at Guy's Hospital, Medical School Building, 3rd Floor, London SE1 9RT, UK.
Nat Med. 1999 Sep;5(9):1004-9. doi: 10.1038/12440.
We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners' mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of CD8 cell-derived suppressor factor activity, RANTES, and macrophage inflammatory proteins 1alpha and 1beta. Allo-immunization also downregulated the proportion of cells with CCR5 and CXCR4 receptors. We also found a dose-dependent decrease in HIV infectivity of CD4+ cells in vitro after allo-immunization with both primary and T-cell line adapted HIV-1. This study provides a rational basis for an alternative or complementary strategy of allo-immunization against HIV infection.
我们评估了一种基于同种异体的疫苗对感染HIV的女性的预防潜力，这些女性通过与其伴侣的单核白细胞进行同种免疫来预防自然复发性流产。在同种免疫后的1个月内，CD8细胞衍生的抑制因子活性、调节激活正常T细胞表达和分泌的趋化因子（RANTES）以及巨噬细胞炎性蛋白1α和1β的浓度显著上调。同种免疫还下调了具有CCR5和CXCR4受体的细胞比例。我们还发现，在用原发性和T细胞系适应性HIV-1进行同种免疫后，体外CD4+细胞的HIV感染性呈剂量依赖性降低。这项研究为针对HIV感染的同种免疫替代或补充策略提供了合理依据。
