Hermanek P
Department of Surgery, University of Erlangen, Germany.
Anticancer Res. 1999 Jul-Aug;19(4A):2771-4.
The finding of single tumor cells or small tumor cell groups in the lymph and blood (including bone marrow aspirations) should be designated as isolated or disseminated tumor cells. The UICC (1992) recommended to identify such findings by the addition of "(i)" (for isolated tumor cells). In contrast, micrometastasis (2 mm or less) should be indicated by the addition of "(mi)". Before introduction of the examination of lymph nodes or bone marrow aspirations regarding isolated (disseminated) tumor cells the methods have to be standardized and the clinical relevance (independent prognostic significance, assistance in selection of patients for adjuvant treatment) has to be evaluated in prospective large scale studies.
在淋巴液和血液（包括骨髓穿刺液）中发现单个肿瘤细胞或小肿瘤细胞团应被认定为孤立或播散性肿瘤细胞。国际抗癌联盟（1992年）建议通过添加“(i)”（用于孤立肿瘤细胞）来标识此类发现。相比之下，微转移（2毫米或更小）应通过添加“(mi)”来表示。在引入关于孤立（播散性）肿瘤细胞的淋巴结或骨髓穿刺液检查之前，必须对方法进行标准化，并在前瞻性大规模研究中评估其临床相关性（独立的预后意义、辅助选择辅助治疗患者）。
