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WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation.

作者信息

Otsuka T, Muramatsu Y, Higaki T, Nakanishi T, Takase S, Hatanaka H, Okamoto M, Hino M, Hashimoto S

机构信息

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.

出版信息

J Antibiot (Tokyo). 1999 Jun;52(6):536-41. doi: 10.7164/antibiotics.52.536.

DOI:10.7164/antibiotics.52.536
PMID:10470677
Abstract

WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine, WF14861 inhibited cathepsins B and L selectively.

摘要

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