Fusetani N, Fujita M, Nakao Y, Matsunaga S, Van Soest R W
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Bioorg Med Chem Lett. 1999 Dec 20;9(24):3397-402. doi: 10.1016/s0960-894x(99)00618-6.
A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng/mL.
