Zurier R B, Rossetti R G, Seiler C M, Laposata M
Division of Rheumatology, University of Massachusetts Medical Center, Worcester 01655-0335, USA.
Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun;60(5-6):371-5. doi: 10.1016/s0952-3278(99)80015-5.
Oils enriched in certain polyunsaturated fatty acids suppress joint pain and swelling in rheumatoid arthritis patients with active synovitis. Because T lymphocyte activation is important for propagation of joint tissue injury in patients with rheumatoid arthritis, we examined the effects of fatty acids added in vitro on proliferation of human T lymphocytes stimulated with monoclonal antibodies to CD3 and CD4. Unsaturated fatty acids reduced T cell proliferation in a dose dependent manner (dihomogammalinolenic acid > gammalinolenic acid > eicosapentaenoic acid > arachidonic acid). Removal of fatty acids from cultures before cell stimulation did not change the effects, but addition of fatty acids after cell stimulation failed to reduce T cell responses. The saturated palmitic acid did not influence T cell growth. These studies indicate that small changes in cellular fatty acids can have profound effects on early events in T cell signaling and on T cell function.
富含某些多不饱和脂肪酸的油类可抑制患有活动性滑膜炎的类风湿关节炎患者的关节疼痛和肿胀。由于T淋巴细胞活化对于类风湿关节炎患者关节组织损伤的扩散很重要，我们研究了体外添加脂肪酸对用抗CD3和CD4单克隆抗体刺激的人T淋巴细胞增殖的影响。不饱和脂肪酸以剂量依赖性方式降低T细胞增殖（二高γ-亚麻酸>γ-亚麻酸>二十碳五烯酸>花生四烯酸）。在细胞刺激前从培养物中去除脂肪酸不会改变效果，但在细胞刺激后添加脂肪酸未能降低T细胞反应。饱和棕榈酸不影响T细胞生长。这些研究表明，细胞脂肪酸的微小变化可对T细胞信号传导的早期事件和T细胞功能产生深远影响。
