Gibbs S R, Mabry R L, Roland P S, Shoup A G, Mabry C S
Department of Otorhinolaryngology, University of Texas Southwestern Medical Center, Dallas 75235-9035, USA.
Otolaryngol Head Neck Surg. 1999 Sep;121(3):283-4. doi: 10.1016/S0194-5998(99)70186-5.
Numerous observers have suggested a relationship between allergy and Meniere's disease, but objective proof has heretofore been limited. Using standard criteria, we studied a group of 7 patients with previously diagnosed Meniere's disease in whom significant allergy to 1 or more inhalants had also been diagnosed. Patients underwent a baseline electrocochleographic study followed by intranasal challenge with a carefully quantified amount of the allergen to which they were most sensitive. This was followed by a second electrocochleogram. Four of the 7 patients demonstrated at least a 15% increase in the summating potential/action potential ratio in 1 ear, associated with the production of subjective inner ear symptoms. We present this protocol as a potentially useful tool to further study whether inhalant allergy may be a causative factor in patients with Meniere's disease.
许多观察家提出过敏与梅尼埃病之间存在关联，但迄今为止，客观证据有限。我们使用标准标准，研究了一组7名先前被诊断为梅尼埃病的患者，这些患者也被诊断出对1种或多种吸入性过敏原存在显著过敏。患者先进行了一次基线耳蜗电图研究，然后用精心定量的他们最敏感的过敏原进行鼻内激发试验。之后再进行第二次耳蜗电图检查。7名患者中有4名患者的一只耳朵的总和电位/动作电位比值至少增加了15%，同时伴有主观内耳症状。我们提出该方案作为一种潜在有用的工具，以进一步研究吸入性过敏是否可能是梅尼埃病患者的致病因素。
