Frodl-Bauch T, Bottlender R, Hegerl U
Department of Clinical Neurophysiology and Department of Psychiatry, Ludwig-Maximilians-Universität München, Deutschland.
Neuropsychobiology. 1999;40(2):86-94. doi: 10.1159/000026603.
The present review focuses on the current knowledge of the neurochemical processes and neuronal structures involved in the generation of P300. The increasing knowledge in this area facilitates the physiological interpretation of P300 findings as well as the link between P300 research and other research findings in biological psychiatry. Concerning the question of neurochemical substrates, the glutamatergic, GABAergic, cholinergic, noradrenergic, dopaminergic and serotonergic influences on P300 are reviewed. The knowledge of the generating structures of P300 is summarized from intracranial studies, magnetoencephalographic investigations, lesion and animal studies.
本综述聚焦于与P300产生相关的神经化学过程和神经元结构的现有知识。该领域不断增加的知识有助于对P300研究结果进行生理学解释，以及P300研究与生物精神病学其他研究结果之间的联系。关于神经化学底物的问题，本文综述了谷氨酸能、γ-氨基丁酸能、胆碱能、去甲肾上腺素能、多巴胺能和5-羟色胺能对P300的影响。P300产生结构的知识是从颅内研究、脑磁图研究、损伤和动物研究中总结出来的。
