Yasoda-Mohan Anusha, Vanneste Sven
Global Brain Health Institute, Trinity College Dublin, D02 R123 Dublin, Ireland.
Trinity College Institute for Neuroscience, Trinity College Dublin, D02 R123 Dublin, Ireland.
Brain Sci. 2024 Jan 16;14(1):86. doi: 10.3390/brainsci14010086.
The predictive coding theory is currently widely accepted as the theoretical basis of perception and chronic perceptual disorders are explained as the maladaptive compensation of the brain to a prediction error. Although this gives us a general framework to work with, it is still not clear who may be more susceptible and/or vulnerable to aberrations in this system. In this paper, we study changes in predictive coding through the lens of tinnitus and pain. We take a step back to understand how the predictive coding system develops from infancy, what are the different neural and bio markers that characterise this system in the acute, transition and chronic phases and what may be the factors that pose a risk to the aberration of this system. Through this paper, we aim to identify people who may be at a higher risk of developing chronic perceptual disorders as a reflection of aberrant predictive coding, thereby giving future studies more facets to incorporate in their investigation of early markers of tinnitus, pain and other disorders of predictive coding. We therefore view this paper to encourage the thinking behind the development of preclinical biomarkers to maladaptive predictive coding.
预测编码理论目前被广泛接受为感知的理论基础，慢性感知障碍被解释为大脑对预测误差的适应不良补偿。尽管这为我们提供了一个总体框架，但仍不清楚谁可能更容易受到该系统异常的影响和/或更易受损。在本文中，我们通过耳鸣和疼痛的视角来研究预测编码的变化。我们退一步来理解预测编码系统从婴儿期如何发展，在急性、过渡和慢性阶段表征该系统的不同神经和生物标志物是什么，以及可能导致该系统异常的因素有哪些。通过本文，我们旨在识别那些可能因异常预测编码而有更高风险发展为慢性感知障碍的人，从而为未来研究在调查耳鸣、疼痛和其他预测编码障碍的早期标志物时提供更多方面的参考。因此，我们认为本文有助于推动针对适应不良预测编码的临床前生物标志物开发背后的思考。
