鉴定巴西亚马孙州麻风病患者分枝杆菌利福平耐药性的主要药物。
Identification of primary drug resistance to rifampin in Mycobacterium leprae strains from leprosy patients in Amazonas State, Brazil.
机构信息
Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil.
Programa de Pós-Graduação em Imunologia Básica e Aplicada, Universidade Federal do Amazonas, Amazonas, Brazil Laboratorio de Micobacteriologia do Instituto Nacional de Pesquisa da Amazônia-INPA, Manaus, Amazonas, Brazil.
出版信息
J Clin Microbiol. 2014 Dec;52(12):4359-60. doi: 10.1128/JCM.01688-14. Epub 2014 Oct 1.
Abstract
The aim of this study was to identify polymorphisms in the folp1, gyrA, and rpoB genes in leprosy patients treated in Amazonas State, Brazil. Among 197 slit-skin smear samples from untreated or relapsed patients, we found three cases of primary resistance to rifampin and one confirmed case of multidrug resistance.
摘要
本研究旨在鉴定巴西亚马逊州接受治疗的麻风病患者中 folp1、gyrA 和 rpoB 基因的多态性。在 197 份未经治疗或复发患者的皮肤切片样本中，我们发现了三例对利福平的原发性耐药和一例确证的耐多药病例。
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