Ozata M, Odabasi Z, Caglayan S, Beyhan Z, Vural O, Ozdemir C
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik-Ankara, Turkey.
J Endocrinol Invest. 1999 Jul-Aug;22(7):508-13. doi: 10.1007/BF03343601.
Several studies based on psychometric tests have determined an impairment of cognitive functions in patients with androgen deficiency. However, little is known about event-related potentials (ERPs) alterations in male hypogonadism. We investigated alterations of ERP in male hypogonadism before and 3 months after gonadotropin treatment. ERPs were elicited in 20 untreated male patients with idiopathic hypogonadotropic hypogonadism (IHH) (mean age: 21.1+/-1.4 years) and in a group of 30 male controls with comparable mean age and educational level. ERP recordings were repeated 3 months after hCG/hMG treatment. Untreated hypogonadal patients had longer mean P300 latencies and increased P300 amplitudes when compared to those in controls (321.6+/-18.5 vs 299.3+/-20.1 msec, p=0.0002; 12.15+/-4.47 vs 9.38+/-3.02 microV, p=0.011, respectively). The mean P300 latencies did not change significantly 3 months after gonadotropin treatment, while P300 amplitudes were decreased significantly. P300 latencies did not correlate with serum testosterone and other hormone levels. We conclude that prolongation of P300 latencies and increased P300 amplitudes are associated with male hypogonadism, but P300 prolongation is not reversed 3 months after gonadotropin treatment. These findings confirm the occurrence of cognitive defects in hypogonadal patients and would support the hypothesis that perinatal androgen deficiency contributes to an insufficient cognitive development.
多项基于心理测量测试的研究已确定雄激素缺乏患者存在认知功能损害。然而，对于男性性腺功能减退患者的事件相关电位（ERP）改变却知之甚少。我们研究了男性性腺功能减退患者在促性腺激素治疗前及治疗3个月后的ERP改变。对20例未经治疗的特发性低促性腺激素性性腺功能减退（IHH）男性患者（平均年龄：21.1±1.4岁）以及30例平均年龄和教育水平相当的男性对照组进行了ERP检测。在hCG/hMG治疗3个月后重复进行ERP记录。与对照组相比，未经治疗的性腺功能减退患者的平均P300潜伏期更长，P300波幅增加（分别为321.6±18.5 vs 299.3±20.1毫秒，p = 0.0002；12.15±4.47 vs 9.38±3.02微伏，p = 0.011）。促性腺激素治疗3个月后，平均P300潜伏期无显著变化，而P300波幅显著降低。P300潜伏期与血清睾酮及其他激素水平无关。我们得出结论，P300潜伏期延长和P300波幅增加与男性性腺功能减退有关，但促性腺激素治疗3个月后P300延长并未逆转。这些发现证实了性腺功能减退患者存在认知缺陷，并支持围产期雄激素缺乏导致认知发育不足的假说。
