Janowsky J S, Oviatt S K, Orwoll E S
Oregon Health Sciences University, Department of Neurology, Portland 97201-3098.
Behav Neurosci. 1994 Apr;108(2):325-32. doi: 10.1037//0735-7044.108.2.325.
Testosterone plays a role in the organization of behavior during development. The authors examined whether testosterone could play a maintenance role in behavior as well. In a double-blind manner, verbal and visual memory, spatial cognition, motor speed, cognitive flexibility, and mood in a group of healthy older men who were supplemented for 3 months with testosterone were assessed. The increase in testosterone levels to 150% of baseline levels resulted in a significant enhancement of spatial cognition, but no change in any other cognitive domain was found. Testosterone supplementation influenced the endogenous production of estradiol, and estradiol was found to have an inverse relationship to spatial cognitive performance. These results suggest that testosterone supplementation can modify spatial cognition in older men; however, it is likely that this occurs through testosterone's influence on estrogen.
睾酮在发育过程中的行为组织中发挥作用。作者还研究了睾酮是否在行为中也能起到维持作用。以双盲方式，对一组健康老年男性进行了为期3个月的睾酮补充，并评估了他们的言语和视觉记忆、空间认知、运动速度、认知灵活性和情绪。睾酮水平升高至基线水平的150%导致空间认知显著增强，但未发现其他任何认知领域有变化。补充睾酮影响了雌二醇的内源性产生，并且发现雌二醇与空间认知表现呈负相关。这些结果表明，补充睾酮可以改变老年男性的空间认知；然而，这很可能是通过睾酮对雌激素的影响而发生的。
