Swerdloff R S, Wang C
Department of Medicine, University of California, Los Angeles, School of Medicine.
West J Med. 1993 Nov;159(5):579-85.
Androgen levels decrease with age in men. Androgen deficiency in men older than 65 years leads to asthenia, a decrease in muscle mass, osteoporosis, and a decrease in sexual activity. Androgen deficiency has been reported to cause changes in mood and cognitive function. The combination of these factors results in impaired quality of life in older men. Androgen replacement therapy in hypogonadal men increases bone and muscle mass, enhances muscle and cardiovascular function, and improves sexual function and general well-being; whether elderly men experience benefits of androgen replacement is not known. These benefits have to be weighed against the possible adverse effects of prostate and cardiovascular diseases. Careful long-term studies are needed to assess the risk-to-reward ratios of androgen or other hormone replacement therapy before treatment strategies similar to estrogen therapy for postmenopausal women are implemented.
男性雄激素水平随年龄增长而下降。65岁以上男性雄激素缺乏会导致乏力、肌肉量减少、骨质疏松以及性活动减少。据报道，雄激素缺乏会引起情绪和认知功能的变化。这些因素共同导致老年男性生活质量受损。性腺功能减退男性接受雄激素替代疗法可增加骨量和肌肉量，增强肌肉和心血管功能，改善性功能和总体健康状况；老年男性是否能从雄激素替代疗法中获益尚不清楚。这些益处必须与前列腺疾病和心血管疾病可能产生的不良影响相权衡。在实施类似于绝经后女性雌激素疗法的治疗策略之前，需要进行仔细的长期研究来评估雄激素或其他激素替代疗法的风险收益比。
