Cao P, De Rango P
Unità Operativa di Chirurgia Vascolare, Università degli Studi, Perugia.
Cardiologia. 1999 Aug;44(8):711-7.
Optimal management of abdominal aortic aneurysm (AAA) remains a challenging surgical problem. Over the last decade surgical and anesthetic improvements have provided perioperative mortality in the 2% range, when elective AAA repair was performed in single Institutions with large vascular experience. However, community- or national-based mortality rates for elective AAA surgery may be as high as 11% or more. Mortality rates associated with ruptured aneurysms remain as high as 90%. AAA prophylactic resection should be indicated when the risk of rupture exceeds the surgical risk. Although the risk of rupture correlates strongly with the diameter of the AAA, there is evidence that other factors can increase the rupture risk: hypertension, chronic pulmonary disease, aneurysm morphology, etc. Establishing a single threshold diameter for AAA repair appears naive. Moreover, AAA primarily affects older patients with other comorbidities that shorten life expectancy and increase perioperative risks: coronary artery disease, renal and pulmonary insufficiency, peripheral artery disease, etc. So that, proper management of individual AAA is based on balancing the perioperative risk, the risk of rupture, and life expectancy. In the subgroup of young healthy patients with additional risk factors for AAA rupture, elective repair at a smaller size (4 to 5.5 cm) may be beneficial if low surgical risk can be assured. In the last decade endovascular repair for AAA treatment has emerged. These less invasive endovascular techniques for AAA repair offer some advantages in terms of reduced patient stress, analgesic requirement, respiratory dysfunction, blood loss, need for intensive care and reduced hospitalization with an early technical success similar to that of open surgical treatment. However, there are no prospective, randomized studies evaluating endovascular treatment of AAA. Moreover, long-term results on the durability of these new techniques are needed to assess endovascular repair as an alternative treatment to prevent the risk of AAA rupture.
腹主动脉瘤(AAA)的最佳管理仍然是一个具有挑战性的外科问题。在过去十年中,手术和麻醉技术的改进使得在具有丰富血管手术经验的单一机构进行择期AAA修复时,围手术期死亡率在2%左右。然而,基于社区或全国范围的择期AAA手术死亡率可能高达11%或更高。与破裂性动脉瘤相关的死亡率仍高达90%。当破裂风险超过手术风险时,应进行AAA预防性切除。虽然破裂风险与AAA直径密切相关,但有证据表明其他因素也可增加破裂风险:高血压、慢性肺病、动脉瘤形态等。为AAA修复设定单一的阈值直径似乎很天真。此外,AAA主要影响患有其他合并症的老年患者,这些合并症会缩短预期寿命并增加围手术期风险:冠状动脉疾病、肾和肺功能不全、外周动脉疾病等。因此,对个体AAA的合理管理基于平衡围手术期风险、破裂风险和预期寿命。在具有AAA破裂额外风险因素的年轻健康患者亚组中,如果能够确保低手术风险,在较小尺寸(4至5.5厘米)时进行择期修复可能是有益的。在过去十年中,出现了用于AAA治疗的血管内修复。这些用于AAA修复的侵入性较小的血管内技术在减轻患者应激、镇痛需求、呼吸功能障碍、失血、重症监护需求以及减少住院时间方面具有一些优势,并且早期技术成功率与开放手术治疗相似。然而,尚无前瞻性、随机研究评估AAA的血管内治疗。此外,需要这些新技术耐久性的长期结果来评估血管内修复作为预防AAA破裂风险的替代治疗方法。