Lehrnbecher T, Venzon D, de Haas M, Chanock S J, Kühl J
Department of Pediatrics, University of Würzburg, Germany.
Clin Infect Dis. 1999 Aug;29(2):414-9. doi: 10.1086/520224.
Circulating levels of interleukin (IL)-6, IL-8, soluble Fc gamma receptor type III (sFc gammaRIII), mannose-binding protein (MBP), and C-reactive protein (CrP) were assessed among febrile children with cancer and neutropenia. Levels of IL-6, IL-8, sFc gammaRIII, MBP, and CrP were measured in serum from 56 pediatric cancer patients at the time of admission for 121 episodes of febrile neutropenia (88 febrile episodes without identifiable source, 5 clinically documented infections, 20 episodes of bacteremia due to gram-positive and 5 due to gram-negative organisms, and 3 fungal infections). IL-6 and IL-8 levels were higher in patients with either bacteremia due to gram-negative organisms or fungal infections than in patients with febrile episodes without an identifiable source (P < .00001 for each). IL-6 and IL-8 levels were higher in children with bacteremia due to gram-negative organisms than in those with bacteremia due to gram-positive organisms (P = .0011 and P = .0003, respectively). The measured levels of CrP, MBP, and sFc gammaRIII were not useful for identifying the type of infection. These preliminary results show the potential usefulness of IL-6 and IL-8 as early indicators for life-threatening infections in febrile cancer patients with neutropenia.
在患有癌症和中性粒细胞减少症的发热儿童中，评估了白细胞介素（IL）-6、IL-8、可溶性Fcγ受体III型（sFcγRIII）、甘露糖结合蛋白（MBP）和C反应蛋白（CrP）的循环水平。在56名儿科癌症患者因121次发热性中性粒细胞减少症入院时（88次无明确病因的发热发作、5次临床记录的感染、20次革兰氏阳性菌血症发作和5次革兰氏阴性菌血症发作以及3次真菌感染），测量了血清中IL-6、IL-8、sFcγRIII、MBP和CrP的水平。革兰氏阴性菌血症或真菌感染患者的IL-6和IL-8水平高于无明确病因发热发作的患者（每种情况P <.00001）。革兰氏阴性菌血症儿童的IL-6和IL-8水平高于革兰氏阳性菌血症儿童（分别为P =.0011和P =.0003）。测量的CrP、MBP和sFcγRIII水平对识别感染类型无用。这些初步结果表明，IL-6和IL-8作为发热性癌症中性粒细胞减少症患者危及生命感染的早期指标具有潜在用途。
