降钙素原和 C 反应蛋白在慢性重型乙型肝炎相关自发性细菌性腹膜炎的诊断和预测中的应用。
Procalcitonin and C-reactive protein in the diagnosis and prediction of spontaneous bacterial peritonitis associated with chronic severe hepatitis B.
机构信息
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, P.R. China.
出版信息
Ann Lab Med. 2013 Nov;33(6):449-54. doi: 10.3343/alm.2013.33.6.449. Epub 2013 Oct 17.
BACKGROUND
Procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBCs) are inflammatory markers used to diagnose severe bacterial infections. We evaluated the diagnostic role of these markers and compared their accuracy for spontaneous bacterial peritonitis (SBP) associated with chronic severe hepatitis B (CSHB).
METHODS
PCT and CRP concentrations, WBC count, and other hematological parameters were measured in serum from 84 well-characterized patients with CSHB, of whom 42 had SBP. Receiver operating characteristics (ROC) curve analysis was performed to assess the diagnostic accuracy.
RESULTS
PCT and CRP concentrations were significantly higher in the CSHB patients with SBP (n=42) than CSHB patients without SBP (n=42). PCT and CRP concentrations were more accurate than WBC count for the diagnosis of CSHB-associated SBP. The optimal cutoff value of PCT was 0.48 ng/mL. The PCT concentration was significantly correlated with the CRP concentration and WBC count.
CONCLUSIONS
Serum PCT and CRP seems to be better markers than WBC for the diagnosis of CSHB patients with SBP.
背景
降钙素原（PCT）、C 反应蛋白（CRP）和白细胞（WBC）是用于诊断严重细菌感染的炎症标志物。我们评估了这些标志物的诊断作用，并比较了它们在慢性重型乙型肝炎（CSHB）相关自发性细菌性腹膜炎（SBP）中的准确性。
方法
对 84 例具有明确特征的 CSHB 患者的血清进行 PCT 和 CRP 浓度、WBC 计数和其他血液学参数的检测，其中 42 例患者患有 SBP。采用受试者工作特征（ROC）曲线分析评估诊断准确性。
结果
患有 SBP（n=42）的 CSHB 患者的 PCT 和 CRP 浓度明显高于未患有 SBP（n=42）的 CSHB 患者。PCT 和 CRP 浓度比 WBC 计数更能准确诊断 CSHB 相关 SBP。PCT 的最佳截断值为 0.48ng/ml。PCT 浓度与 CRP 浓度和 WBC 计数呈显著相关。
结论
与 WBC 相比，血清 PCT 和 CRP 似乎是诊断 CSHB 患者 SBP 的更好标志物。
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