Kern W V, Heiss M, Steinbach G
Department of Medicine, Section of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center, D-89070 Ulm, Germany.
Clin Infect Dis. 2001 Mar 1;32(5):832-5. doi: 10.1086/319207. Epub 2001 Feb 23.
In a prospective observational study of 133 neutropenic episodes, interleukin (IL)-8 serum levels > 2000 pg/mL at the onset of fever had a sensitivity of 53% and a specificity of 97% as a predictor of gram-negative bacteremia (GNB; positive predictive value, 73%; negative predictive value, 94%). The rates of early death differed significantly between patients with high and those with low IL-8 levels (3/11 vs. 1/122; P< .01). Serum IL-8 levels at the onset of fever define a low-risk subgroup of patients who can safely be treated with monotherapy.
在一项针对133例中性粒细胞减少发作的前瞻性观察研究中，发热开始时白细胞介素（IL）-8血清水平>2000 pg/mL作为革兰氏阴性菌血症（GNB）预测指标的敏感性为53%，特异性为97%（阳性预测值为73%；阴性预测值为94%）。IL-8水平高和低的患者早期死亡率有显著差异（3/11对1/122；P<0.01）。发热开始时的血清IL-8水平确定了一组低风险患者亚群，这些患者可安全地接受单一疗法治疗。
